uncovered the molecular mechanism by which retinoic acid induces the transition of embryonic stem cell to a 2-cell like state, implicating DUX and DUXbl1 in this process ( Tagliaferri et al.). The 12 selected manuscripts, highlighted in this topic, were not part of a research topic but have caught our attention and that of the readers by their scope, novelty and quality.įour primary research manuscripts were chosen to be part of this Editors’ pick. This Editors’ pick research topic aims to highlight a few of the most noteworthy manuscripts published in the Stem Cell section of Frontier in Cell and Development al Biology over 20. Stem cell biology and regenerative medicine can be systematized by combining these fundamental technologies related to developmental biology and stem cells. For example, the use of signal transduction mimicking the developmental stages of tissues to induce specific cell differentiation, the construction of target tissues by organoid culture, a three-dimensional culture method, and the use of exosomes, which play an important role in cell-cell communication, have recently attracted attention. The use of these stem/progenitor cells has been further enhanced by genetic engineering and embryological strategies ( Wang et al., 2021). Tissue-specific stem/progenitor cells that can be isolated from various adult tissues can contribute to the specific tissue types for physiological tissue maintenance and repair after damage ( Prentice, 2019). In addition, mesenchymal stem cells (MSCs) derived from bone marrow are known as multipotent adult stem cells ( Gao et al., 2021), capable of differentiating into various mesenchymal cells and have contributed to regenerative medicine as have biological microdevices. Stem cells include embryonic stem cells ( Martin, 1981 Thomson et al., 1998) with pluripotent differentiation ability retained by fertilized eggs, and induced Pluripotent Stem (iPS) cells ( Takahashi et al., 2007 Takahashi and Yamanaka, 2006), which have been developed by cell culture and molecular biological technologies. Current knowledge of stem cell biology, as well as various cell culture technologies that have been established in recent years, supports the field of developmental biology and regenerative medicine ( Ikeya et al., 2021a, b).
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